α3β4 nachr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9542	NS3861		AChR
	NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...		AChR
T2422	PNU-282987		AChR
	PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).		AChR
TP2063	α-Conotoxin MII		AChR
	α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuro...		AChR
T23388	SR 16584		Others
	α3β4 nAChR antagonist		Others
T9450	NS3861 fumarate
	NS3861 fumarate is an agonist of nicotinic acetylcholine receptors (nAChRs). NS3861 fumarate is a partial agonist at α3β4 nAChR and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7...
T0072	Adiphenine hydrochloride	Adiphenine HCl,Spasnil,Patrovina,Sentiv	AChR
	Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.		AChR
T39833	(Rac)-CP-601927 hydrochloride
	(Rac)-CP-601927 hydrochloride is the racemate form of CP-601927, which is a nicotinic acetylcholine receptor (nAChR) agonist. It exhibits Ki values of 1.2 nM and 102 nM for α4β2 and α3β4 nAChR, respectively.
T75877	α-Conotoxin AuIB TFA
	α-Conotoxin AuIB TFA, a potent selective antagonist of the α3β4 nicotinic acetylcholine receptor (nAChR), effectively inhibits nAChRs expressed in Xenopus oocytes, demonstrating an inhibitory concentration (IC 50) of 0.7...
T80219	α-Conotoxin TxID
	α-Conotoxin TxID is a potent antagonist of the α3β4 nicotinic acetylcholine receptor (nAChR), exhibiting an inhibitory half-maximal inhibitory concentration (IC50) of 12.5 nM. Its inhibitory activity against the closely ...
T70987	AT-1001
	AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversib...
T80475	α-Conotoxin AuIA
	α-Conotoxin AuIA, isolated from Conus aulicus [1], is a potent and selective inhibitor of α3β4 nicotinic acetylcholine receptors (nAChRs).
T73894	α-Conotoxin Vc1.1 TFA
	α-Conotoxin Vc1.1 TFA, a disulfide-bonded peptide derived from Conus victoriae, selectively antagonizes nAChRs. It effectively inhibits the α3α5β2, α3β2, and α3β4 nAChR subtypes with IC50 values of 7.2 μM, 7.3 μM, and 4....
T40119	TC-2559 difumarate
	TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist with an EC 50 of 0.18 μM. It exhibits selectivity for α4β2 receptors over α2β4, α4β4, and α3β...
T4246L	Varenicline
	Varenicline (CP 526555), a cytisine-based nicotinic ligand, is a potent partial agonist for the α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM and acts as a full agonist for α7 and α3β4 nAChRs...
T80166	α-Conotoxin BuIA
	α-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for α6/α3β2, 1.54 nM for α...
T37202	CC4	CC4
	High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for huma...
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) la...
T35432	α-Conotoxin ImI (trifluoroacetate salt)
	α-Conotoxin ImI is a conotoxin that has been found inC. imperialisand has receptor antagonist and anticancer activities.1It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50= 220 nM)...